Lambda-CDM predicts that quantum field theory's vacuum energy density should be approximately 10^{120} times larger than the observed cosmological constant, creating one of the most severe discrepancies in physics. The theory cannot explain why the vacuum energy is so small or why it happens to equal the matter density today, requiring catastrophic fine-tuning or unknown cancellation mechanisms. This "worst prediction in physics" reveals a fundamental incompatibility between quantum mechanics and general relativity at cosmic scales, suggesting that either dark energy is not vacuum energy, or both QFT and the cosmological model require radical revision (Hobson et al. 2006; Perlmutter 2003). Lambda-CDM offers no coherent mechanism to resolve this 120-order-of-magnitude discrepancy without invoking anthropic reasoning or undiscovered physics.